Wine-processed radix scutellariae alleviates ARDS by regulating tryptophan metabolism through gut microbiota.

ABSTRACT: Acute respiratory distress syndrome (ARDS) is an acute and diffuse pulmonary inflammation, characterized by severe hypoxic respiratory failure caused by inflammatory tissue damage, which is a common cause of respiratory failure. Currently, there is no treatment available that can prevent or reverse the devastating effects caused by these conditions. The purpose of this study was to determine the effects of WRS on gut microbiota and the potential effect of gut microbiota on the treatment of lung disease by using a staphylococcal enterotoxin B (SEB)-induced ARDS model. The results showed that WRS could significantly reduce the pathological damage to lung and colon tissues and improve the lung and intestinal functions of ARDS mice. WRS was able to improve the level of cytokines in serum and l

SUBMITTER: Hu T 

PROVIDER: S-EPMC9849372 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature