Distinct components of cardiovascular health are linked with age-related differences in cognitive abilities.

ABSTRACT: Cardiovascular ageing contributes to cognitive impairment. However, the unique and synergistic contributions of multiple cardiovascular factors to cognitive function remain unclear because they are often condensed into a single composite score or examined in isolation. We hypothesized that vascular risk factors, electrocardiographic features and blood pressure indices reveal multiple latent vascular factors, with independent contributions to cognition. In a population-based deep-phenotyping study (n = 708, age 18-88), path analysis revealed three latent vascular factors dissociating the autonomic nervous system response from two components of blood pressure. These three factors made unique and additive contributions to the variability in crystallized and fluid intelligence. The discrepancy

SUBMITTER: King DLO 

PROVIDER: S-EPMC9849401 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature