The Strain Response to Intraocular Pressure Decrease in the Lamina Cribrosa of Patients with Glaucoma.

ABSTRACT:

Objective

To measure biomechanical strains in the lamina cribrosa (LC) of living human eyes with intraocular pressure (IOP) lowering.

Design

Cohort study.

Participants

Patients with glaucoma underwent imaging before and after laser suturelysis after trabeculectomy surgery (29 image pairs; 26 persons).

Intervention

Noninvasive imaging of the eye.

Main outcome measures

Strains in optic nerve head tissue and changes in depths of the anterior border of the LC.

Results

Intraocular pressure decreases caused the LC to expand in thickness in the anterior-posterior strain (E_zz = 0.94 ± 1.2%; P = 0.00020) and contract in radius in the radial strain (E_rr = - 0.19 ± 0.33%; P = 0.0043). The mean LC depth did not significantly change with

SUBMITTER: Czerpak CA 

PROVIDER: S-EPMC9849479 | biostudies-literature | 2023 Jan-Feb

REPOSITORIES: biostudies-literature