Monocyte subtype expression patterns in septic patients with diabetes are distinct from patterns observed in obese patients.

ABSTRACT:

Background

Sepsis causes a high rate of mortality and long-term morbidity, associated with an imbalance of innate immunity against infections and inflammation. Obesity and diabetes increase the risk for disease severity. Monocyte dysfunction plays a major role and justify further investigations.

Objective

To investigate the distribution and inflammatory phenotypes in circulating monocyte subsets in patients manifesting with sepsis including septic shock with and without obesity and diabetes.

Methods

A total of 235 blood samples were tested from critically ill adult patients registered at the intensive care unit (ICU). The cohorts were divided into non-diabetic groups with or without obesity and diabetic groups with or without obesity, suffering from sepsis or septic s

SUBMITTER: Ning D 

PROVIDER: S-EPMC9849690 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature