L-shaped association of serum calcium with all-cause and CVD mortality in the US adults: A population-based prospective cohort study.

ABSTRACT:

Background

Calcium is involved in many biological processes, but the impact of serum calcium levels on long-term mortality in general populations has been rarely investigated.

Methods

This prospective cohort study analyzed data from the National Health and Nutrition Examination Survey (1999-2018). All-cause mortality, cardiovascular disease (CVD) mortality, and cancer mortality were obtained through linkage to the National Death Index. Survey-weighted multivariate Cox regression was performed to compute hazard ratios (HRs) and 95% confidential intervals (CIs) for the associations of calcium levels with risks of mortality. Restricted cubic spline analyses were performed to examine the non-linear association of calcium levels with all-cause and disease-specific mortality.

R

SUBMITTER: Hou X 

PROVIDER: S-EPMC9849810 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature