Vitamin D Receptor Gene Polymorphism ApaI as a Predisposing Factor for Psoriasis and Its Relation With Serum Vitamin D Levels and Psoriasis Severity.

ABSTRACT:

Background and aim

Psoriasis is a chronic, relapsing and inflammatory multisystemic disease with both genetic predisposition and autoimmune pathogenic traits. Several types of vitamin D receptor (VDR) polymorphisms have been investigated as a predisposing factor for psoriasis susceptibility with controversial results. However, the exact pathophysiological effect of the VDR gene on psoriasis susceptibility remains poorly understood. We aimed to determine whether VDR gene polymorphisms, specifically rs7975232 (ApaI), afford psoriasis susceptibility in a given community in Saudi Arabia. Also, to assess its possible relation with disease severity.

Subjects and methods

In a comparative case-control study comprising 53 psoriatic patients and 41 matched healthy controls, we measure

SUBMITTER: Alhetheli G 

PROVIDER: S-EPMC9849829 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature