Xanthine oxidase, a therapeutic target of realgar for non-small cell lung cancer.

ABSTRACT:

Background

The effects of realgar against non-small cell lung cancer (NSCLC) have been massively studied, but the direct therapeutic targets of realgar remain unclear. This study aimed to identify the molecular targets of realgar against NSCLC and explore their therapeutic mechanisms based on a network pharmacology approach and experimental validations.

Methods

The BATMAN-TCM and Digsee databases were used to predict realgar targets and NSCLC-related genes, respectively. A protein-protein interaction network was constructed for each gene set, and the overlapping genes were identified as potential targets of realgar against NSCLC. The correlation between potential targets and NSCLC was analyzed using The Cancer Genome Atlas and International Cancer Genome Consortium databases

SUBMITTER: Guo R 

PROVIDER: S-EPMC9849977 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature