Longitudinal changes in ¹⁸F-Flutemetamol amyloid load in cognitively intact APOE4 carriers versus noncarriers: Methodological considerations.

ABSTRACT:

Purpose

Measuring longitudinal changes in amyloid load in the asymptomatic stage of Alzheimer's disease is of high relevance for clinical research and progress towards more efficacious, timely treatments. Apolipoprotein E ε4 (APOE4) has a well-established effect on the rate of amyloid accumulation. Here we investigated which region of interest and which reference region perform best at detecting the effect of APOE4 on longitudinal amyloid load in individuals participating in the Flemish Prevent Alzheimer's Disease Cohort KU Leuven (F-PACK).

Methods

Ninety cognitively intact F-PACK participants (baseline age: 68 (52-80) years, 46 males, 42 APOE4 carriers) received structural MRI and ¹⁸F-Flutemetamol PET scans at baseline and follow-up (6.2 (3.4-10.9) year interval)

SUBMITTER: Luckett ES 

PROVIDER: S-EPMC9850036 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature