Crosstalk between imbalanced gut microbiota caused by antibiotic exposure and rotavirus replication in the intestine.

ABSTRACT:

Objective

Rotavirus (RV), one of non-enveloped double-strained RNA viruses, can cause infantile diarrheal illness. It is widely accepted that RV is transmitted mainly via feces-oral route. However, infected asymptomatic adults are becoming the source of infection. It is necessary to explore the underlying mechanism of RV replication in adult's intestine.

Methods

After recruiting healthy volunteers and RV asymptomatic carriers, we firstly investigated the association of animal-derived food intake with antibiotic level in urine samples. Secondly, we compared the difference in the structure of gut microbiota, and identified the taxa that most likely explained the difference. Finally, we investigated the impact of lipopolysaccharide (LPS), produced by gram-negative bacteria, on

SUBMITTER: Li Y 

PROVIDER: S-EPMC9850052 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature