Cross-species high-resolution transcriptome profiling suggests biomarkers and therapeutic targets for ulcerative colitis.

ABSTRACT: Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an essential role in studying its molecular pathophysiology. Here, we aim to identify common conserved pathological UC-related gene expression signatures between humans and mice that can be used as treatment targets and/or biomarker candidates. Methods: To identify differentially regulated protein-coding genes and non-coding RNAs, we sequenced total RNA from the colon and blood of the most widely used dextran sodium sulfate Ulcerative colitis mouse. By combining this with public human Ulcerative colitis data, we investigated conserved gene expression signatures and pathways/biological processes through which these genes may contribute to disease development/progression. Results:

SUBMITTER: Yarani R 

PROVIDER: S-EPMC9850088 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature