Short-term exposure to fine particulate matter and genome-wide DNA methylation in chronic obstructive pulmonary disease: A panel study conducted in Beijing, China.

ABSTRACT:

Background

Fine particulate matter (PM_2.5) is a crucial risk factor for chronic obstructive pulmonary disease (COPD). However, the mechanisms whereby PM_2.5 contribute to COPD risk have not been fully elucidated. Accumulating evidence suggests that epigenetics, including DNA methylation, play an important role in this process; however, the association between PM_2.5 exposure and genome-wide DNA methylation in patients with COPD has not been studied.

Objective

To evaluate the association of personal exposure to PM_2.5 and genome-wide DNA methylation changes in the peripheral blood of patients with COPD.

Methods

A panel study was conducted in Beijing, China. We repeatedly measured and collected personal PM_2.5 data for

SUBMITTER: Duan R 

PROVIDER: S-EPMC9850166 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature