The clinical application of ⁶⁸Ga-PSMA PET/CT and regulating mechanism of PSMA expression in patients with brain metastases of lung cancer.

ABSTRACT: Brain metastases (BMs) of lung cancer are common malignant intracranial tumours associated with severe neurological symptoms and an abysmal prognosis. Prostate-specific membrane antigen (PSMA) has been reported to express significantly in a variety of solid tumours. However, the clinical applications of ⁶⁸Ga-PSMA PET/CT and the mechanism of PSMA expression in patients with BMs of lung cancer have rarely been reported. Experiments with ⁶⁸Ga-PSMA PET/CT and immunohistochemical staining were conducted to evaluate the expression of PSMA from seven patients with BMs of lung cancer who accepted surgical treatment in Fudan University Shanghai Cancer Center between October 2020 and October 2021. The mechanism of PSMA expression in BMs of lung cancer was explored by using sing

SUBMITTER: Pei Y 

PROVIDER: S-EPMC9850174 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature