Pemafibrate therapy for non-alcoholic fatty liver disease is more effective in lean patients than obese patients.

ABSTRACT:

Introduction

Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, with an increasing incidence. Pemafibrate is a novel selective peroxisome proliferator-activated receptor-a (PPAR-a) modulator which is expected to improve NAFLD. The aim of this study is to identify predictors of improvement of hepatic inflammation and fibrosis after pemafibrate therapy in patients with NAFLD.

Material and methods

Seventy-one non-diabetic patients with NAFLD treated with pemafibrate for more than six months were included in this retrospective review. Hepatic inflammation and fibrosis were evaluated by alanine aminotransferase (ALT) and Mac-2 binding protein glycosylation isomer (M2BPGi) levels, respectively.

Results

During six months of pemaf

SUBMITTER: Shinozaki S 

PROVIDER: S-EPMC9850303 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature