Thermostable negative-marker foot-and-mouth disease virus serotype O induces protective immunity in guinea pigs.

ABSTRACT: Foot-and-mouth disease (FMD) is a contagious viral disease of high economic importance, caused by FMD virus (FMDV), a positive-sense single-stranded RNA virus, affecting cloven-hoofed animals. Preventive vaccination using inactivated virus is in practice to control the disease in many endemic countries. While the vaccination induces antibodies mainly to structural proteins, the presence of antibodies to the non-structural proteins (NSP) is suggestive of infection, a criterion for differentiation of infected from vaccinated animals (DIVA). Also, there is a growing demand for enhancing the stability of the FMD vaccine virus capsid antigen as the strength of the immune response is proportional to the amount of intact 146S particles in the vaccine. Considering the need for a DIVA compliant sta

SUBMITTER: Ranjitha HB 

PROVIDER: S-EPMC9850340 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature