Effect of Vitamin D₃ Supplementation on Acute Fracture Healing: A Phase II Screening Randomized Double-Blind Controlled Trial.

ABSTRACT: Nearly half of adult fracture patients are vitamin D deficient (serum 25-hydroxyvitamin D [25(OH)D] levels <20 ng/mL). Many surgeons advocate prescribing vitamin D supplements to improve fracture healing outcomes; however, data supporting the effectiveness of vitamin D₃ supplements to improve acute fracture healing are lacking. We tested the effectiveness of vitamin D₃ supplementation for improving tibia and femur fracture healing. We conducted a single-center, double-blinded phase II screening randomized controlled trial with a 12-month follow-up. Patients aged 18-50 years receiving an intramedullary nail for a tibia or femoral shaft fracture were randomized 1:1:1:1 to receive (i) 150,000 IU loading dose vitamin D₃ at injury and 6 weeks (n = 

SUBMITTER: Slobogean GP 

PROVIDER: S-EPMC9850434 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature