Dynamical Models of Chemical Exchange in Nuclear Magnetic Resonance Spectroscopy.

ABSTRACT: Chemical exchange line-broadening is an important phenomenon in nuclear magnetic resonance (NMR) spectroscopy, in which a nuclear spin experiences more than one magnetic environment as a result of chemical or conformational changes of a molecule. The dynamic process of chemical exchange strongly affects the sensitivity and resolution of NMR experiments, and increasingly provides a powerful probe of the inter-conversion between chemical and conformational states of proteins, nucleic acids, and other biological macromolecules. A simple and often used theoretical description of chemical exchange in NMR spectroscopy is based on an idealized two-state jump model (the random-phase or telegraph signal). However, chemical exchange can also be represented as a barrier-crossing event that can be mod

SUBMITTER: Daffern N 

PROVIDER: S-EPMC9850547 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature