Modulation of the microbiota across different intestinal segments by Rifaximin in PI-IBS mice.

ABSTRACT:

Background

Rifaximin has been increasingly applied in irritable bowel syndrome (IBS) treatment. Whether there were differences in the effects of rifaximin on microbiota from different intestinal segments, especially the small intestine where rifaximin predominantly acted, has not been confirmed.

Methods

In this study, we used Trichinella spiralis infection to induce post infectious irritable bowel syndrome (PI-IBS) and measured visceral sensitivity of mice by means of abdominal withdrawal reflex (AWR) tests to colorectal distention (CRD). We compared the effects of rifaximin on the composition of ileal, colonic mucosal and fecal microbiota in PI-IBS mice.

Results

Rifaximin significantly reduced AWR scores and increased pain threshold in PI-IBS mice, and this effect wa

SUBMITTER: Zhang S 

PROVIDER: S-EPMC9850553 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature