Ferroptosis related gene signature in T cell-mediated rejection after kidney transplantation.

ABSTRACT:

Background

T cell-mediated rejection is an important factor affecting early transplant kidney survival. Ferroptosis has been shown to play a pathogenic role in a variety of diseases, which was not reported in TCMR. Here we developed a model for assessing activation of ferroptosis-related genes in TCMR to find a better screening method and explore the contribution of ferroptosis in TCMR.

Methods

We performed unsupervised consensus clustering according to expression of ferroptosis-related genes based on RNA-seq data from kidney transplant biopsies, and developed an assessment model characterized by ferroptosis gene expression through PCA, which was evaluated in multiple external datasets as well as blood and urine samples. Pathway enrichment and immune cell infiltration analys

SUBMITTER: Zhang W 

PROVIDER: S-EPMC9850582 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature