Pan-3D genome analysis reveals structural and functional differentiation of soybean genomes.

ABSTRACT:

Background

High-order chromatin structure plays important roles in gene regulation. However, the diversity of the three-dimensional (3D) genome across plant accessions are seldom reported.

Results

Here, we perform the pan-3D genome analysis using Hi-C sequencing data from 27 soybean accessions and comprehensively investigate the relationships between 3D genomic variations and structural variations (SVs) as well as gene expression. We find that intersection regions between A/B compartments largely contribute to compartment divergence. Topologically associating domain (TAD) boundaries in A compartments exhibit significantly higher density compared to those in B compartments. Pan-3D genome analysis shows that core TAD boundaries have the highest transcription start site (TSS) d

SUBMITTER: Ni L 

PROVIDER: S-EPMC9850592 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature