Investigation of Neurofunctional Changes Over the Course of Electroconvulsive Therapy.

ABSTRACT:

Background

Electroconvulsive therapy (ECT) is an effective treatment for patients suffering from depression. Yet the exact neurobiological mechanisms underlying the efficacy of ECT and indicators of who might respond best to it remain to be elucidated. Identifying neural markers that can inform about an individual's response to ECT would enable more optimal treatment strategies and increase clinical efficacy.

Methods

Twenty-one acutely depressed inpatients completed an emotional working memory task during functional magnetic resonance imaging before and after receiving treatment with ECT. Neural activity was assessed in 5 key regions associated with the pathophysiology of depression: bilateral dorsolateral prefrontal cortex and pregenual, subgenual, and dorsal anterior cingu

SUBMITTER: Gruzman R 

PROVIDER: S-EPMC9850659 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature