Effect of common pregnancy and perinatal complications on offspring metabolic traits across the life course: a multi-cohort study.

ABSTRACT:

Background

Common pregnancy and perinatal complications are associated with offspring cardiometabolic risk factors. These complications may influence multiple metabolic traits in the offspring and these associations might differ with offspring age.

Methods

We used data from eight population-based cohort studies to examine and compare associations of pre-eclampsia (PE), gestational hypertension (GH), gestational diabetes (GD), preterm birth (PTB), small (SGA) and large (LGA) for gestational age (vs. appropriate size for gestational age (AGA)) with up to 167 plasma/serum-based nuclear magnetic resonance-derived metabolic traits encompassing lipids, lipoproteins, fatty acids, amino acids, ketones, glycerides/phospholipids, glycolysis, fluid balance, and inflammation. Confounder

SUBMITTER: Elhakeem A 

PROVIDER: S-EPMC9850719 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature