Design, Synthesis, and Bioactivity of Chalcone Derivatives Containing Indanone.

ABSTRACT: A series of chalcone derivatives containing indanone were designed and synthesized by aldehyde-ketone condensation and etherification. The activity test demonstrated that the majority of the compounds had good therapeutic and protective activities against tobacco mosaic virus (TMV) at a concentration of 500 μg/mL when being tested. Among them, the target compounds N2 and N7 showed good therapeutic activities against TMV with EC₅₀ values of 70.7 and 89.9 μg/mL, respectively, which were better than that of ningnanmycin (158.3 μg/mL). N2 and N10 showed better protective activities against TMV with EC₅₀ values of 60.8 and 120.3 μg/mL, which were superior to that of ningnanmycin (175.6 μg/mL). A hydrogen bond interaction was observed between

SUBMITTER: Sun N 

PROVIDER: S-EPMC9850732 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature