LRRC superfamily expression in stromal cells predicts the clinical prognosis and platinum resistance of ovarian cancer.

ABSTRACT:

Background

Leucine-rich repeat sequence domains are known to mediate protein‒protein interactions. Recently, some studies showed that members of the leucine rich repeat containing (LRRC) protein superfamily may become new targets for the diagnosis and treatment of tumours. However, it is not known whether any of the LRRC superfamily genes is expressed in the stroma of ovarian cancer (OC) and is associated with prognosis.

Methods

The clinical data and transcriptional profiles of OC patients from the public databases TCGA (n = 427), GTEx (n = 88) and GEO (GSE40266 and GSE40595) were analysed by R software. A nomogram model was also generated through R. An online public database was used for auxiliary analysis of prognosis, immune infiltration and protein‒protein interaction (P

SUBMITTER: Zhu X 

PROVIDER: S-EPMC9850808 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature