Impaired Experience-Dependent Refinement of Place Cells in a Rat Model of Alzheimer's Disease.

ABSTRACT:

Background

Hippocampal place cells play an integral role in generating spatial maps. Impaired spatial memory is a characteristic pathology of Alzheimer's disease (AD), yet it remains unclear how AD influences the properties of hippocampal place cells.

Objective

To record electrophysiological activity in hippocampal CA1 neurons in freely-moving 18-month-old male TgF344-AD and age-matched wild-type (WT) littermates to examine place cell properties.

Methods

We implanted 32-channel electrode arrays into the CA1 subfield of 18-month-old male WT and TgF344-AD (n = 6/group) rats. Ten days after implantation, single unit activity in an open field arena was recorded across days. The spatial information content, in-field firing rate, and stability of each place cell was compare

SUBMITTER: Broussard JI 

PROVIDER: S-EPMC9850819 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature