Risk Factors for Incident Inflammatory Bowel Disease According to Disease Phenotype.

ABSTRACT:

Background & aims

We examined whether relationships between known risk factors for Crohn's disease (CD) and ulcerative colitis (UC) differ according to disease phenotype, defined by Montreal classification, at the time of diagnosis.

Methods

We performed a prospective cohort study of 208,070 adults from the Nurses' Health Study (NHS), NHSII, and Health Professionals Follow-Up Study (HPFS). Dietary, lifestyle, and medical data were obtained at baseline and every 2-4 years. We confirmed cases of inflammatory bowel disease (IBD) and their phenotypes via medical record review. We tested for heterogeneity across CD subtypes using the likelihood ratio test and for linear heterogeneity across UC subtypes using the meta-regression method.

Results

We ascertained 346 cases of CD

SUBMITTER: Lopes EW 

PROVIDER: S-EPMC9850926 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature