LAMP2 regulates autophagy in the thymic epithelium and thymic stroma-dependent CD4 T cell development.

ABSTRACT: Within the thymus, thymic epithelial cells (TECs) provide dedicated thymic stroma microenvironments for T cell development. Because TEC functionality is sensitive to aging and cytoablative therapies, unraveling the molecular elements that coordinate their thymopoietic role has fundamental and clinical implications. Particularly, the selection of CD4 T cells depends on interactions between TCRs expressed on T cell precursors and self-peptides:MHC II complexes presented by cortical TECs (cTECs). Although the macroautophagy/autophagy-lysosomal protein degradation pathway is implicated in CD4 T cell selection, the molecular mechanism that controls the generation of selecting MHC II ligands remains elusive. LAMP2 (lysosomal-associated membrane protein 2) is a well-recognized mediator of autolys

SUBMITTER: Rodrigues PM 

PROVIDER: S-EPMC9851248 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature