Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma.

ABSTRACT:

Background

Asthma is characterized by morphological modifications of the airways (inflammation and remodelling) and bronchial hyperresponsiveness. Mechanisms linking these two key features of asthma are still poorly understood. ADAM28 (a disintegrin and metalloproteinase 28) might play a role in asthma pathophysiology. ADAM28 exists as membrane-bound and soluble forms and is mainly expressed by lymphocytes and epithelial cells.

Methods

ADAM28^-/- mice and ADAM28^+/+ counterparts were sensitized and exposed to ovalbumin (OVA). Airway responsiveness was measured using the flexiVent^® system. After sacrifice, bronchoalveolar lavage (BAL) was performed and lungs were collected for analysis of airway inflammation and remodelling.

Results

The e

SUBMITTER: Bendavid G 

PROVIDER: S-EPMC9851272 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature