Diabetes and Excess Aldosterone Promote Heart Failure With Preserved Ejection Fraction.

ABSTRACT: Background The pathobiology of heart failure with preserved ejection fraction (HFpEF) is still poorly understood, and effective therapies remain limited. Diabetes and mineralocorticoid excess are common and important pathophysiological factors that may synergistically promote HFpEF. The authors aimed to develop a novel animal model of HFpEF that recapitulates key aspects of the complex human phenotype with multiorgan impairments. Methods and Results The authors created a novel HFpEF model combining leptin receptor-deficient db/db mice with a 4-week period of aldosterone infusion. The HFpEF phenotype was assessed using morphometry, echocardiography, Ca²⁺ handling, and electrophysiology. The sodium-glucose cotransporter-2 inhibitor empagliflozin was then tested for reversin

SUBMITTER: Hegyi B 

PROVIDER: S-EPMC9851441 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature