Ontology highlight
ABSTRACT:
SUBMITTER: Mironov A
PROVIDER: S-EPMC9851507 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Mironov Aleksandr A Fisher Matthew M Narayanan Priya P Elsayed Randa R Karabulutoglu Melis M Akhtar Nasreen N
PLoS biology 20230119 1
Cell turnover in adult tissues is essential for maintaining tissue homeostasis over a life span and for inducing the morphological changes associated with the reproductive cycle. However, the underlying mechanisms that coordinate the balance of cell death and proliferation remain unsolved. Using the mammary gland, we have discovered that Rac1 acts as a nexus to control cell turnover. Postlactational tissue regression is characterised by the death of milk secreting alveoli, but the process is rev ...[more]