Circadian variation of serum leptin and adipose tissue changes in children.

ABSTRACT:

Background

Higher morning serum leptin values are associated with larger adipose tissue gains in children; however, it is unclear if leptin circadian variation is itself associated with adipose tissue changes during growth.

Objective

We studied the association of circadian variation in leptin with change in total body fat mass (TBFM), total body percentage fat (%FM), and trunk fat mass (TrFM).

Methods

Baseline serum samples for leptin were obtained every 3 h for 24 h from 130 children (baseline age 9.6 ± 2.5y; 51.1% male; BMI-Z 1.59) with mean follow-up of 11.1 ± 4.0y and underwent dual-energy x-ray absorptiometry. ANCOVA models examined change in TBFM, %FM, or TrFM as dependent variables and number of years of follow-up, sex, race, baseline age, pubertal status, init

SUBMITTER: Zenno A 

PROVIDER: S-EPMC9851946 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature