Amount of Pannexin 1 in Smooth Muscle Cells Regulates Sympathetic Nerve-Induced Vasoconstriction.

ABSTRACT:

Background

Panx1 (pannexin 1) forms high conductance channels that secrete ATP upon stimulation. The role of Panx1 in mediating constriction in response to direct sympathetic nerve stimulation is not known. Additionally, it is unknown how the expression level of Panx1 in smooth muscle cells (SMCs) influences α-adrenergic responses. We hypothesized that the amount of Panx1 in SMCs dictates the levels of sympathetic constriction and blood pressure.

Methods

To test this hypothesis, we used genetically modified mouse models enabling expression of Panx1 in vascular cells to be varied. Electrical field stimulation on isolated arteries and blood pressure were assessed.

Results

Genetic deletion of SMC Panx1 prevented constriction by electric field stimulation of sympathetic n

SUBMITTER: Dunaway LS 

PROVIDER: S-EPMC9851955 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature