Systolic Blood Pressure Time in Target Range and Major Adverse Kidney and Cardiovascular Events.

ABSTRACT:

Background

Whether time-in-target range (TTR) for systolic blood pressure (SBP) associates with adverse kidney and cardiovascular events remains incompletely understood.

Methods

This study included participants in 2 clinical trials that compared intensive (<120 mm Hg) and standard (<140 mm Hg) SBP lowering. SBP-TTR for months 0 to 3 was calculated using therapeutic ranges of 110 to 130 mm Hg and 120 to 140 mm Hg for the intensive and standard arms, respectively. Adverse kidney events included the composite of dialysis, kidney transplant, serum creatinine >3.3 mg/dL, sustained eGFR <15 mL/(min·1.73 m²), or sustained eGFR decline >40%. Adverse cardiovascular events included myocardial infarction, stroke, heart failure, and cardiovascular death. Adjusted Cox proporti

SUBMITTER: Buckley LF 

PROVIDER: S-EPMC9851984 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature