Temporal Dynamics of the Scale for the Assessment and Rating of Ataxia in Spinocerebellar Ataxias.

ABSTRACT:

Background

The Scale for the Assessment and Rating of Ataxia (SARA) is the reference clinical scale to assess the severity of cerebellar ataxia. In the context of upcoming therapeutic trials, a reliable clinical outcome is needed to assess the efficiency of treatments.

Objective

The aim is to precisely assess and compare temporal dynamics of SARA and a new f-SARA.

Methods

We analyzed data from four cohorts (EUROSCA, RISCA, CRC-SCA, and SPATAX) comprising 1210 participants and 4092 visits. The linearity of the progression and the variability were assessed using an ordinal Bayesian mixed-effect model (Leaspy). We performed sample size calculations for therapeutic trials with different scenarios to improve the responsiveness of the scale.

Results

Seven of the eigh

SUBMITTER: Moulaire P 

PROVIDER: S-EPMC9851985 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature