Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation.

ABSTRACT: Programming T cells to distinguish self from non-self is a vital, multi-step process that occurs in the thymus^1-4. Signalling through the pre-T cell receptor (preTCR), a CD3-associated heterodimer comprising an invariant pTα chain and a clone-specific β chain, is a critical early checkpoint in thymocyte development within the αβ T cell lineage^5,6. PreTCRs arrayed on CD4^-CD8^- double-negative thymocytes ligate peptides bound to major histocompatibility complex molecules (pMHC) on thymic stroma, similar to αβ T cell receptors that appear on CD4⁺CD8⁺ double-positive thymocytes, but via a different molecular docking strategy^7-10. Here we show the consequences of these distinct interactions for thymocyte progression usi

SUBMITTER: Duke-Cohan JS 

PROVIDER: S-EPMC9851994 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature