Associations of maternal insulin sensitivity during pregnancy with childhood central adiposity in the Genetics of Glucose regulation in Gestation and Growth (Gen3G) cohort.

ABSTRACT:

Background

Childhood obesity has been associated with prenatal exposure to maternal hyperglycaemia, but we lack understanding about maternal insulin physiologic components that contribute to this association.

Objectives

Evaluate the association between maternal insulin sensitivity during pregnancy and adiposity measures in childhood.

Methods

In 422 mother-child pairs, we tested associations between maternal insulin sensitivity measures at ~26 weeks of pregnancy and child adiposity measures, including dual-energy X-ray absorptiometry body composition and anthropometry (body mass index and waist circumference) at ~5 years. We used linear regression analyses to adjust for maternal age, ethnicity, gravidity, first-trimester body mass index, and child sex and age at mid-ch

SUBMITTER: Ghildayal N 

PROVIDER: S-EPMC9852010 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature