Peptide Amphiphile Mediated Co-assembly for Nanoplasmonic Sensing.

ABSTRACT: Aromatic interactions are commonly involved in the assembly of naturally occurring building blocks, and these interactions can be replicated in an artificial setting to produce functional materials. Here we describe a colorimetric biosensor using co-assembly experiments with plasmonic gold and surfactant-like peptides (SLPs) spanning a wide range of aromatic residues, polar stretches, and interfacial affinities. The SLPs programmed in DDD-(ZZ)_x -FFPC self-assemble into higher-order structures in response to a protease and subsequently modulate the colloidal dispersity of gold leading to a colorimetric readout. Results show the strong aggregation propensity of the FFPC tail without polar DDD head. The SLPs were specific to the target protease, i.e., M^pro , a biomarker

SUBMITTER: Jin Z 

PROVIDER: S-EPMC9852014 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature