Chronic Kidney Disease Induces Proarrhythmic Remodeling.

ABSTRACT:

Background

Patients with chronic kidney disease (CKD) are at increased risk of developing cardiac arrhythmogenesis and sudden cardiac death; however, the basis for this association is incompletely known.

Methods

Here, using murine models of CKD, we examined interactions between kidney disease progression and structural, electrophysiological, and molecular cardiac remodeling.

Results

C57BL/6 mice with adenine supplemented in their diet developed progressive CKD. Electrocardiographically, CKD mice developed significant QT prolongation and episodes of bradycardia. Optical mapping of isolated-perfused hearts using voltage-sensitive dyes revealed significant prolongation of action potential duration with no change in epicardial conduction velocity. Patch-clamp studies of i

SUBMITTER: King BMN 

PROVIDER: S-EPMC9852080 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature