TSPO PET signal using [¹⁸F]GE180 is associated with survival in recurrent gliomas.

ABSTRACT:

Purpose

Glioma patients, especially recurrent glioma, suffer from a poor prognosis. While advances to classify glioma on a molecular level improved prognostication at initial diagnosis, markers to prognosticate survival in the recurrent situation are still needed. As 18 kDa translocator protein (TSPO) was previously reported to be associated with aggressive histopathological glioma features, we correlated the TSPO positron emission tomography (PET) signal using [¹⁸F]GE180 in a large cohort of recurrent glioma patients with their clinical outcome.

Methods

In patients with [¹⁸F]GE180 PET at glioma recurrence, [¹⁸F]GE180 PET parameters (e.g., SUV_max) as well as other imaging features (e.g., MRI volume, [¹⁸F]FET PET paramete

SUBMITTER: Quach S 

PROVIDER: S-EPMC9852133 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature