¹⁸F-sodium fluoride PET-CT visualizes both axial and peripheral new bone formation in psoriatic arthritis patients.

ABSTRACT:

Purpose

As bone formation is associated with psoriatic arthritis (PsA), positron emission tomography (PET) using a ¹⁸F-Fluoride tracer may enable sensitive detection of disease activity. Our primary aim was to determine the feasibility of whole-body ¹⁸F-sodium fluoride PET-CT in clinically active PsA patients to depict new bone formation (as a reflection of disease activity) at peripheral joints and entheses. Our secondary aim was to describe ¹⁸F-sodium fluoride findings in the axial skeleton.

Methods

Sixteen patients (female 10/16, age 50.6 ± 8.9 years) with PsA fulfilling CASPAR criteria or with a clinical diagnosis of PsA according to the treating rheumatologist and with ≥ 1 clinically active enthesitis site were included. Of each patient,

SUBMITTER: de Jongh J 

PROVIDER: S-EPMC9852163 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature