Role of brain 2-[¹⁸F]fluoro-2-deoxy-D-glucose-positron-emission tomography as survival predictor in amyotrophic lateral sclerosis.

ABSTRACT:

Purpose

The identification of prognostic tools in amyotrophic lateral sclerosis (ALS) would improve the design of clinical trials, the management of patients, and life planning. We aimed to evaluate the accuracy of brain 2-[¹⁸F]fluoro-2-deoxy-D-glucose-positron-emission tomography (2-[¹⁸F]FDG-PET) as an independent predictor of survival in ALS.

Methods

A prospective cohort study enrolled 418 ALS patients, who underwent brain 2-[¹⁸F]FDG-PET at diagnosis and whose survival time was available. We discretized the survival time in a finite number of classes in a data-driven fashion by employing a k-means-like strategy. We identified "hot brain regions" with maximal power in discriminating survival classes, by evaluating the Laplacian scores in a c

SUBMITTER: Canosa A 

PROVIDER: S-EPMC9852209 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature