Modulation of methamphetamine memory reconsolidation by neural projection from basolateral amygdala to nucleus accumbens.

ABSTRACT: Drug-associated conditioned cues promote subjects to recall drug reward memory, resulting in drug-seeking and reinstatement. A consolidated memory becomes unstable after recall, such that the amnestic agent can disrupt the memory during the reconsolidation stage, which implicates a potential therapeutic strategy for weakening maladaptive memories. The basolateral amygdala (BLA) involves the association of conditioned cues with reward and aversive valences and projects the information to the nucleus accumbens (NAc) that mediates reward-seeking. However, whether the BLA-NAc projection plays a role in drug-associated memory reactivation and reconsolidation is unknown. We used methamphetamine (MeAM) conditioned place preference (CPP) to investigate the role of BLA-NAc neural projection in the

SUBMITTER: Li JY 

PROVIDER: S-EPMC9852248 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature