Transcriptomic response of bioengineered human cartilage to parabolic flight microgravity is sex-dependent.

ABSTRACT: Spaceflight and simulated spaceflight microgravity induced osteoarthritic-like alterations at the transcriptomic and proteomic levels in the articular and meniscal cartilages of rodents. But little is known about the effect of spaceflight or simulated spaceflight microgravity on the transcriptome of tissue-engineered cartilage developed from human cells. In this study, we investigate the effect of simulated spaceflight microgravity facilitated by parabolic flights on tissue-engineered cartilage developed from in vitro chondrogenesis of human bone marrow mesenchymal stem cells obtained from age-matched female and male donors. The successful induction of cartilage-like tissue was confirmed by the expression of well-demonstrated chondrogenic markers. Our bulk transcriptome data via RNA sequen

SUBMITTER: Aissiou AK 

PROVIDER: S-EPMC9852254 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature