Associations of sNfL with clinico-radiological measures in a large MS population.

ABSTRACT:

Objective

Evaluation of serum neurofilament light chain (sNfL), measured using high-throughput assays on widely accessible platforms in large, real-world MS populations, is a critical step for sNfL to be utilized in clinical practice.

Methods

Multiple Sclerosis Partners Advancing Technology and Health Solutions (MS PATHS) is a network of healthcare institutions in the United States and Europe collecting standardized clinical/imaging data and biospecimens during routine clinic visits. sNfL was measured in 6974 MS and 201 healthy control (HC) participants, using a high-throughput, scalable immunoassay.

Results

Elevated sNfL levels for age (sNfL-E) were found in 1238 MS participants (17.8%). Factors associated with sNfL-E included male sex, younger age, progressive disea

SUBMITTER: Sotirchos ES 

PROVIDER: S-EPMC9852396 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature