A comprehensive investigation into the genetic relationship between music engagement and mental health.

ABSTRACT: While music engagement is often regarded as beneficial for mental health, some studies report higher risk for depression and anxiety among musicians. This study investigates whether shared underlying genetic influences (genetic pleiotropy) or gene-environment interaction could be at play in the music-mental health association using measured genotypes. In 5,648 Swedish twins with information on music and sport engagement, creative achievements, self-reported mental health and psychiatric diagnoses based on nationwide patient registries, we derived polygenic scores for major depression, bipolar disorder, schizophrenia, neuroticism, sensitivity to environmental stress, depressive symptoms and general musicality. In line with phenotypic associations, individuals with higher polygenic scores fo

SUBMITTER: Wesseldijk LW 

PROVIDER: S-EPMC9852421 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature