Bioprinting microporous functional living materials from protein-based core-shell microgels.

ABSTRACT: Living materials bring together material science and biology to allow the engineering and augmenting of living systems with novel functionalities. Bioprinting promises accurate control over the formation of such complex materials through programmable deposition of cells in soft materials, but current approaches had limited success in fine-tuning cell microenvironments while generating robust macroscopic morphologies. Here, we address this challenge through the use of core-shell microgel ink to decouple cell microenvironments from the structural shell for further processing. Cells are microfluidically immobilized in the viscous core that can promote the formation of both microbial populations and mammalian cellular spheroids, followed by interparticle annealing to give covalently stabilized

SUBMITTER: Ou Y 

PROVIDER: S-EPMC9852579 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature