Type 2 cytokine genes as allergic asthma risk factors after viral bronchiolitis in early childhood.

ABSTRACT:

Background

Genome-wide association studies of asthma have identified associations with variants in type-2 related genes. Also, specific interactions between genetic variants and viral bronchiolitis in the development of asthma has been suggested.

Objective

To conduct a gene-based analysis of genetic variants in type 2 cytokine related genes as risk factors for allergic asthma at school age, and further, to study their interaction with specific viral infections in early childhood.

Methods

A prospectively investigated cohort of children with previous bronchiolitis and controls came for follow-up at school age. The research visit, blinded to viral exposure, included detailed lung function tests, laboratory investigation, and questionnaires. Allergic asthma was defined as

SUBMITTER: Dong Z 

PROVIDER: S-EPMC9852873 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature