Bispecific killer cell engager with high affinity and specificity toward CD16a on NK cells for cancer immunotherapy.

ABSTRACT:

Introduction

The Fc region of monoclonal antibodies (mAbs) interacts with the CD16a receptor on natural killer (NK) cells with "low affinity" and "low selectivity". This low affinity/selectivity interaction results in not only suboptimal anticancer activity but also induction of adverse effects. CD16a on NK cells binds to the antibody-coated cells, leading to antibody-dependent cell-mediated cytotoxicity (ADCC). Recent clinical data have shown that the increased binding affinity between mAb Fc region and CD16a receptor is responsible for significantly improved therapeutic outcomes. Therefore, the objective of this study was to develop a bispecific killer cell engager (BiKE) with high affinity and specificity/selectivity toward CD16a receptor for NK cell-based cancer immunoth

SUBMITTER: Nikkhoi SK 

PROVIDER: S-EPMC9852913 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature