Gyrification patterns in first-episode, drug-naive major depression: Associations with plasma levels of brain-derived neurotrophic factor and psychiatric symptoms.

ABSTRACT:

Background and objectives

Cortical structural changes in major depressive disorder (MDD) are usually studied using a voxel-based morphometry approach to delineate the cortical gray matter volume. Among cortical structures, gyrification patterns are considered a relatively stable indicator. In this study, we investigated differences in gyrification patterns between MDD patients and healthy controls (HCs) and explored the association of gyrification patterns with plasma brain-derived neurotrophic factor (BDNF) levels and depressive symptoms in MDD patients.

Methods

We evaluated 79 MDD patients and 94 HCs and assessed depression severity in the patients using the 17-item Hamilton Depression Rating Scale (HAM-D). Blood samples of both groups were collected to measure plasma BDNF

SUBMITTER: Natsuyama T 

PROVIDER: S-EPMC9852994 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature