Impact of frailty on early rhythm control outcomes in older adults with atrial fibrillation: A nationwide cohort study.

ABSTRACT:

Purpose

Rhythm-control therapy administered early following the initial diagnosis of atrial fibrillation (AF) has superior cardiovascular outcomes compared to rate-control therapy. Frailty is a key factor in identifying older patients' potential for improvement after rhythm-control therapy. This study evaluated whether frailty affects the outcome of early rhythm-control therapy in older patients with AF.

Methods

From the Korean National Health Insurance Service database (2005-2015), we collected 20,611 populations aged ≥65 years undergoing rhythm- or rate-control therapy initiated within 1 year of AF diagnosis. Participants were emulated by the EAST-AFNET4 trial, and stratified into non-frail, moderately frail, and highly frail groups based on the hospital frailty risk score

SUBMITTER: Yu GI 

PROVIDER: S-EPMC9853018 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature