Dietary fiber intake and non-alcoholic fatty liver disease: The mediating role of obesity.

ABSTRACT:

Background and aims

Dietary pattern rich in fiber is negatively associated with the risk of non-alcoholic fatty liver disease (NAFLD). Meanwhile, obesity is a known predisposing factor for NAFLD. Nutrient-focused research can enhance the mechanistic understanding of dietary effects. We thus hypothesized that higher dietary fiber intake was associated with lower risk of NAFLD through the mediating role of obesity.

Methods

In this nationwide cross-sectional study, dietary fiber was surveyed using two 24-h recalls. NAFLD and clinically significant fibrosis (CSF) were determined by vibration-controlled transient elastography. Multivariable logistic and linear regression were applied to investigate the association of dietary fiber with NAFLD, CSF, and liver function parameters. W

SUBMITTER: Zhu Y 

PROVIDER: S-EPMC9853063 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature